Biology and Epidemiology of Malaria Recurrence: Implication for Control and Elimination

Malaria recurrence not only increases its clinical episodes, but also sustains transmission. It significantly contributes to a high burden of malaria and impedes elimination. can be due reinfection, relapse, or recrudescence. Based on the type recurrence, parasites exhibit similar dissimilar genotypes compared genotype involved in initial infection. This review aimed at showing comprehensive overview recurrence. Molecular techniques, such as real-time polymerase chain reaction (PCR), nested PCR, multiplex sequencing, help characterize However, these tools are hardly accessible malaria-endemic areas unable detect liver hypnozoites. Moreover, PCR is adequately differentiate between relapse reinfection P. vivax. Recurrent malaria, particularly accounts for major portion prevalence. Through renewed parasitemia, remained daunting public health problem. More works remain overcome challenges efforts control eliminate malaria. Limited understanding development robust strategies effective mitigation. Continued biological epidemiological studies unravel persistent complexities develop ideal tool fight